Author(s):
1. Josipa Karij Trivunović, Univerzitet u Banjoj Luci, Medicinski fakultet, studijski program Dentalna medicina, Republic of Srpska, Bosnia and Herzegovina
2. Vladan Mirjanić, Medicinski fakultet Banja Luka , Republic of Srpska, Bosnia and Herzegovina

Abstract:
Bone possesses an exceptional regenerative capacity, and most injuries heal without the formation of scar tissue. However, various local and systemic factors can compromise bone healing and result in the formation of bone defects. In such cases, surgical methods can be used to stimulate bone regeneration. Autogenous and allogeneic bone, xenogeneic grafts, and alloplastic materials—used either alone or in combination with membranes in the technique of guided bone regeneration (GBR)—have been employed for many years to restore bone tissue. Platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and plasma rich in growth factors (PRGF) are preparations obtained by centrifugation of the patient's blood and represent an optimized blood clot. The use of platelet preparations can enhance the healing process by promoting neoangiogenesis, fibroblast proliferation, collagen formation, mitosis of mesenchymal stem cells, and osteoblasts.

Key words:
bone regeneration,GBR,platelet preparations,BMP

Thematic field:
SYMPOSIUM B - Biomaterials and nanomedicine

Date of abstract submission:
02.07.2025.

Conference:
Contemporary Materials 2025 - Savremeni Materijali

Abstract